The ASBMB-BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity

October 21
Registration open 12:00-7:00 pm
Dinner: 5:30-7:00 pm
7:00-7:10	Opening remarks
7:10-7:15	Introduction to Keynote Speaker Bruce Stillman by Zhiguo Zhang
7:15-8:00	Keynote Address I: Bruce Stillman, Cold Spring Harbor Laboratory, USA Title: Biochemical Investigation and Evolutionary Comparison of the Initiation of DNA Replication in Eukaryotic Cells
8:00-10:00 pm	Session 1: Mechanisms of chromatin replication Chairs: Andrei Chabes, University of Umeå, Sweden, and Qing Li, Peking University, China.
8:00-8:20	Chunlong Chen, Curie Institute, France Title: Decipher DNA replication program of human cells at the single-molecule and single-cell levels
8:20-8:35	Jiazhi Hu, Peking University, China Title: DNA replication forks are coupled together to maintain genome integrity
8:35-8:50	Break
8:50-9:10	Andrei Chabes, University of Umeå, Sweden Title: Impact of nucleoside supplementation on dNTP and rNTP pools and DNA replication dynamics
9:10-9:25	Chuanhe Yu, Hormel Institute, University of Minnesota, USA Title: Replication Fork Structure Regulates Parental Histone Recycling
9:25-9:40	Yuanlian Zhai, The University of Hong Kong, China Title: Structural insights into the functions of the replisome in chromatin replication
9:40-10:00	Qing Li, Peking University, China Title: Nucleosome assembly, epigenetic inheritance, and beyond

Tuesday (Day 2)
9:00 am-12:00 pm	Session 2: Repairing the epigenome Evi Soutoglou, University of Sussex, UK, and Feilong Meng, Shanghai Institute of Biochemistry and Cell Biology, China.
9:00-9:20	Kyle Miller, Emory School of Medicine, USA Title: Function of Bromodomain Proteins in Replication Stress and Telomere Maintenance
9:20-9:40	Rushad Pavri, King’s College London, UK Title: Regulation of somatic hypermutation by higher order chromatin structure
9:40-9:55	Yunpeng Feng, Northeast Normal University, China Title: O-GlcNAcase OGA protects replication fork and genome stability upon replication stress
9:55-10:15	Feilong Meng, Shanghai Institute of Biochemistry and Cell Biology, China Title: Mechanism of Transcription-coupled DNA Damage in Immune Diversification
10:15-10:30	Yang Yu, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, China Title: Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
10:30-10:50	Coffee break and group photo
10:50-11:10	Supriya Prasanth, University of Illinois Urbana-Champaign, USA Title: ORCA/LRWD1 organizes 3D-genome through the polycomb repressive complex
11:10-11:25	Francis Stewart, Key State Laboratory for Microbial Technologies, Shandong University, Qingdao, China Title: CHROMATIN TETHERING BY THE TRITHORAX HOMOLOG, MLL2, DURING THE ESC NAÏVE TO PRIMED TRANSITION
11:40-12:00	Evi Soutoglou, University of Sussex, UK Title: Genome organization in DNA repair pathway choice and mutagenesis
12:00-1:30 pm	Lunch
1:30-3:30 pm	Poster session 1
3:30-5:20 pm	Session 3: Structural and functional insights into chromatin replication and repair Chair: Rui-Ming Xu, Institute of Biophysics, Chinese Academy of Sciences, China
3:30-3:50	Wei Yang, NIH, USA Title: Stitching up Double-strand breaks
3:50-4:05	Peng Yang: Tongji University, China Title: A KRAB-ZFP promotes neurogenesis in the cerebellum by preserving DNA methylation
4:05-4:20	Yarui Du, Center for Excellence in Molecular Cell Science, China Title: Transmission of DNA Methylation from Parents to Embryos: Insights into Maternal and Paternal
4:20-4:40	Rui-Ming Xu, Institute of Biophysics, Chinese Academy of Sciences, China Title: Mechanism of genome targeting by LINE-1
4:40-5:00	Hongtao Yu, Westlake University, China Title: A safety latch for Mcm2-7 loading
5:00-5:15	Tao Chen, Founder & CEO of Absea Group Title：Platforms and Resources for Proteomics and Beyond
5:15-7:10 pm	Dinner
7:10-10:00 pm	Session 4: Modifying the epigenome to maintain genomic integrity in cancer Chair: Jessica Tyler, Weill Cornell Medicine, USA, and Zhenkun Lou, Mayo Clinic Rochester, USA.
7:10-7:30	Philipp Oberdoerffer, Johns Hopkins University, USA Title: Epigenetic control of Topoisomerase 1 activity as a cancer vulnerability
7:30-7:50	Zhenkun Lou, Mayo Clinic Rochester, USA Title: NSD3 Confers PARP Inhibitor Resistance in Prostate Cancer
7:50-8:05	Chul-Hwan Lee, Seoul National University, South Korea Title: PRC2-EZH1 Mediated Chromatin Compaction and its Oncogenic Potential in Thyroid Cancer
8:05-8:20	Kui ming Chan, City University of Hong Kong, China Title: Histone H2B mutations in cancer development
8:20-8:40	Peter Lewis, University of Wisconsin, USA Title: Aberrant Heterochromatin in Human Cancers
8:40-9:00	Coffee break
9:00-9:20	Xuefeng Chen, Wuhan University, China Title: Rtt105 stimulates Rad51-ssDNA assembly and orchestrates Rad51 and RPA actions to promote homologous recombination repair
9:20-9:40	Jessica Tyler, Weill Cornell Medicine, USA Title: Loss of nucleolar integrity in budding yeast is a mortality timer
9:40-10:00	Wei-Guo Zhu, Shenzhen University, China Title: PRC2-mediated WDR5 methylation regulates H3K4me3 and gene expression

Wednesday (Day 3)
9:00 am-12:00 pm	Session 5: Genome maintenance during growth, development and carcinogenesis (morning) Chair: Yi Zhang, Harvard Medical School, USA, and Xiaobing Shi, Van Andel Institute, USA.
9:00-9:20	Bing Zhu, Institute of Biophysics, Chinese Academy of Sciences, China Title: Initiation & Restriction of Heterochromatin
9:20-9:40	Xiang David Li, Hong Kong University, China Title: Chemical approaches to decoding histone epigenetics
9:40-9:55	Yafen Wang: Wuhan University, China Title: Innovative Probes for High-Resolution Detection of Epigenetic Modification Nucleobases and Their Clinical Applications
9:55-10:10	Wei Wu, Center for Excellence in Molecular Cell Science, CAS, China Title: Profiling instability at repetitive regions
10:10-10:30	Yi Zhang, HHMI/Harvard Medical School, USA Title: Reducing functionally defective HSCs alleviates aging-related phenotypes in old mice
10:30-10:50	Coffee break
10:50-11:10	Hua Lu, Tulane University, USA Title: Role of Mutant p53 in Liver Cancer Development
11:10-11:25	Xi Wang, Beijing Institute of Infectious Diseases, China Title: Epigenetic Regulation of TIGIT Expression in NK Cells: Unraveling the Role of TNF-alpha Signaling in Cancer Immunotherapy
11:25-11:40	Dan Zhou, Fudan University, China Title: Identification of leukemia-derived neomorphic mutations of TET2
11:40-12:00	Xiaobing Shi, Van Andel Institute, USA Title: Histone acetylation: reading, writing, and beyond
12:00-1:30 pm	Lunch
Free Afternoon and Evening

Thursday (Day 4)
9:00 am-12:00 pm	Session 6: Chromosome dynamics during genome maintenance Chair: Guo-Ming Li, CIMR, China, and Jun Huang, Zhejiang University, China.
9:00-9:20	Rodney Rothstein, Columbia University Irving Medical Center, USA Title: Replication stress promotes mitotic recombination, loss of heterozygosity and aneuploidy in Saccharomyces Cerevisiae
9:20-9:40	Guo-Ming Li, CIMR, China Title: Role of DNA mismatch repair in replication stress response
9:40-10:00	Dirk Remus, Memorial Sloan Kettering Cancer Center, USA Title: Cryo-EM structures of G4-stalled CMG reveal inchworm mechanism of DNA translocation
10:00-10:15	Zhi Qi, Peking University, China Title: ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
10:15-10:30	Jian Ouyang, Medical University of South Carolina, USA Title: Local RNA transcript promotes homologous recombination repair of DNA double-strand breaks by forming DR-loops
10:30-10:50	Coffee break
10:50-11:10	Andre Nussenzweig, NIH, USA Title: Distinct roles of BRCA1 and 53BP1 at replication-coupled and canonical DNA double strand breaks
11:10-11:30	Patrick Sung, UT Health San Antonio, USA Title: Homologous Recombination Licensing Role of the Tumor Suppressor Complex BRCA1-BARD1
11:30-11:45	Tingting Yao, Colorado State University, USA Title: A live-cell sensor for BRCA1-BARD1 mediated H2A ubiquitylation
11:45-12:05	Jun Huang, Zhejiang University, China Title: Replication fork reversal and protection
12:05-1:30 pm	Lunch
1:30-3:30 pm	Poster session 2
3:30-5:25 pm	Session 7: Chromatin remodeling and modification to maintain genomic integrity Chair: Geeta Narlikar, UCSF, USA, and Brian Strahl, University of North Carolina, USA.
3:30-3:50	Brian Strahl, University of North Carolina, USA Title: A SETD2-CDK1-Lamin axis maintains nuclear integrity and genome stability
3:50-4:05	Haining Du, Wuhan University, China Title: SETD3 inhibits non-small cell lung carcinoma progression via regulating cytokinetic abscission
4:05-4:20	Hong Wen, Van Andel Institute, USA Title: The histone acetylation reader ENL in cancer
4:20-4:35	Scott B. Rothbart, Van Andel Institute, USA Title: Mechanisms of crosstalk between DNA methylation and histone post-translational modifications
4:35-4:55	Geeta Narlikar, UCSF, USA Title: ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers
4:55-5:10	Zhucheng Chen, Tsinghua University, School of Life Sciences, China Title: Mechanism of chromatin remodeling from structures of ISWI in the presence of ATP hydrolysis
5:10-5:25	Zenqi Wen, Shenzhen Campus of Sun Yat-sen University, China Title: Nucleosome wrapping states encode principles of 3D genome organization
6:00 pm	Banquet

Friday (Day 5)
9:00 am-12:00 pm	Announcement of poster prize winners
9:00-9:05	Introduction to Keynote Speaker Danny Reinberg by Guohong Li
9:05-9:50	Keynote Address II: Danny Reinberg, University of Miami, USA Title: Polycomb, Inheritance and Disease
9:50-12:00 pm	Session 8: Nucleosome assembly during DNA replication and repair Chairs: Danesh Moazed, Harvard University, USA, and David MacAlpine, Duke University, USA.
9:50-10:10	Zhiguo Zhang, Columbia University Irving Medical Center, USA Title: A tale of two strands: decoding chromatin replication using strand-specific sequencing
10:10-10:30	David MacAlpine, Duke University, USA Title: Strand-specific and differential kinetics of chromatin maturation at the replication fork in histone chaperone mutants
10:30-10:45	Coffee break
10:45-11:05	Guohong Li, Wuhan University, China Title: HIRA complex pioneers meiotic double strand breaks by recruiting PRDM9
11:05-11:20	Fu Yang, Wuhan University, China Title: Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis
11:20-11:40	Danesh Moazed, Harvard University, USA Title: Parental histone transfer to newly replicated DNA and its role in heterochromatin inheritance
11:40-12:00	Closing remarks and poster awards

The ASBMB-BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity

October 21-25, 2024 Wuhan · China

The ASBMB-BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity

October 21-25, 2024
Wuhan · China

Program

October 21

Tuesday (Day 2)

Wednesday (Day 3)

Thursday (Day 4)

Friday (Day 5)

Registration

Program & Abstract

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