王祥喜
Xiangxi Wang

Ph.D., Principal Investigator
Institute of Biophysics, CAS, China

中国科学院生物物理研究所研究员

王祥喜研究员长期从事病毒入侵、复制与组装分子机制。运用低温冷冻电镜、病毒学、细胞生物学等技术方法，从事人类重大疾病直接相关的病毒完整颗粒及病毒与受体、病毒与抗体的超大分子复合物的精细三维结构和相关功能研究，揭示病毒入侵宿主细胞的分子机制和致病机理以及抗病毒药物研究。主要研究方向包括：1.疱疹病毒的复制、组装和运输机制；2.脑炎性黄病毒神经毒力的分子机制；3.非洲猪瘟病毒、新型冠状病毒的免疫机制与疫苗设计。 

Research Interests
Viral diseases are serious public health threats and have caused considerable concern over public health safety. Despite outnumbering all other cellular forms of life, our knowledge of the viral life cycle remains limited. During the viral life cycle, most viruses undergo a series of conformational changes from the immature to the mature, uncoatingor fusogenic form of the virion. In the infected cells, newly assembled immature viruses mature via structural transformations triggered by limited proteolysis or acidic pH or host factors. The virus systems selected are representatives from three families of virus that we have studied for several years, the Picornaviridae, Flaviviridae and Herpesviradae. My research aims to completely understand the various steps of the virus cycle, including the entry, replication and assembly using a combination of structural analysis, cellular assays, virological, reverse genetics and animal studies. The study of virus cycle facilitates the design of better antiviral compounds and vaccines, which is in agreement with our commitment to translate our research findings into health benefits.