Xiuwu Bian

PH.D., Professor, CASM
Third Military Medical University 

Resume

Director of the Department of Pathology, Army Military Medical University, Director of the Department of Pathology at the First Affiliated Hospital, and Director of the Institute of Clinical Pathology of the PLA. "Changjiang Scholar" Distinguished Professor of the Ministry of Education, winner of the National Outstanding Youth Fund Project. "Key research field innovation team" and the National Natural Science Foundation of China "Innovative Research Group" academic leader. He is also the chairman of the Chinese Medical Doctor Association's Pathologist Branch, the vice chairman of the Chinese Cell Biology Society Stem Cell Biology Branch, and a member of the Standing Committee of the Chinese Medical Association Pathology Branch. Engaged in pathology teaching, diagnosis and research for more than 30 years, and is good at neuropathological (tumor) diagnosis. The research direction is cancer stem cells and tumor microenvironment. Propose a new theory of "tumor microvascular architecture phenotype", clarify related mechanisms, and establish a diagnostic system based on tumor vascular pathology; discover the key role and mechanism of tumor stem cells in tumor angiogenesis, invasion and metastasis, and explore tumor immune microenvironment research New fields; take the lead in formulating a number of tumor pathological diagnosis norms and industry standards. As the corresponding author, he has published more than 130 SCI papers in Nature, Science, Cell Stem Cell, Nature Neuroscience and other journals. The research results won the first prize of the National Science and Technology Progress Award (the first person to complete), the He Liang He Li Foundation "Science and Technology Progress Award" and the first National Innovation Competition Award, and he was named a national model teacher.

Selected publications

1、Liu X#＊, Wang Y＊, Lu H＊, Li J, Yan X, Xiao M, Hao J, Hoang ON, Khong H, Chen T, Huang R, Wu J, Zhao QW, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X, Nurieva R, Ye L, Tian Q, Bian XW#, Dong C#. Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction. Nature, 2019, Mar;567(7749):525-529. (IF 42.778)

2、Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, Zhang X, Zuo Y, Chen L, Zhao Q, Shi Y, Wang F, Yan X, Lu H, Xu S, Yao X, Chen L, Zhang X, Tian Q, Yang Z, Zhong B, Dong C, Wang Y, Bian XW#, Liu X#, SOSTDC1-producing follicular helper T cells promote__regulatory follicular T cell differentiation. Science. 2020 Aug 21;369(6506):984-988. (IF 41.845)

3、Jin G＊, Xu C＊, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW#, Lin HK#. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol, 2018 Jan;19(1):29-40. (IF 23.530)

4、Zhou W＊, Chen C, Shi Y, Wu Q, Gimple RC, Fang X, Huang Z, Zhai K, Ke SQ, Ping YF, Feng H, Yu JS, Rich JN, Bao S#, Bian XW#. Targeting glioma stem cell-derived pericytes disrupts blood-tumor barriers to enhance efficacy of chemotherapy in glioblastoma. Cell Stem Cell, 2017 Nov 2;21(5):591-603. (IF 23.29)

5、Yao XH, He ZC, Li TY, Zhang HR, Wang Y, Mou H, Guo Q, Yu SC, Ding Y, Liu X, Ping YF, Bian XW#. Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient. Cell Res. 2020 Jun;30(6):541-543. (IF= 20.507)

6、Wang J＊, Xu SL＊, Duan JJ＊, Yi L＊, Guo YF, Shi Y, Li L, Yang ZY, Liao XM, Cai J, Zhang YQ, Xiao HL, Yin L, Wu H, Zhang JN, Lv SQ, Yang QK, Yang XJ, Jiang T, Zhang X, Bian XW#, Yu SC#, Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Nat Neurosci, 2019 May;22(5):840.. （IF 20.071）

7、Wang Q, Jiang J, Ying G, Xie XQ, Zhang X, Xu W, Zhang X, Song E, Bu H, Ping YF, Yao XH, Wang B, Xu S, Yan ZX, Tai Y, Hu B, Qi X, Wang YX, He ZC, Wang Y, Wang JM, Cui YH, Chen F, Meng K, Wang Z, Bian XW#. Tamoxifen enhances stemness and promotes metastasis of ERα36+ breast cancer by upregulating ALDH1A1 in cancer cells. Cell Res, 2018 Mar;28(3):336-358. (IF 17.848)

8、Shi Y＊, Guryanova OA, Zhou W, Liu C, Huang Z, Fang X, Wang X, Chen, Wu Q, He Z, Wang W, Zhang W, Jiang T, Liu Q, Chen Y, Wang W, Wu J, Kim L, Gimple RC, Feng H, Kung HF, Jennifer S. Yu JS, Rich JN, Ping YF#, Bian XW#, Bao S#. Ibrutinib targets glioma stem cells by disrupting the BMX- mediated STAT3 activation to suppress malignant growth and radioresistance of glioblastoma. Sci Transl Med, 2018 May 30;10(443). (IF 17.161)

9、Bian XW# and the COVID-19 Pathology Team. Autopsy of COVID-19 victims in China. Natl. Sci. Rev. 2020. June 06. (IF= 16.693)

10、Liu Q*, Shi Y*, Cai J,*, Duan YQ*, Wang RS*, Zhang HY*,Ruan QR*, Li JS*,Zhao L*, Ping YF*, Chen R*, Ren L*, Fei XC, Zhang H,Tang R,Wang X, Luo T, Liu XD, Huang XQ, Liu ZH, Ao QL, Ren Y, Xiong J, He ZC, Wu HB, Fu WJ, Zhao PN, Chen XW, Qu GQ, Wang YY, Wang X, Liu J, Xiang DF, Xu SP, Zhou XW, Li QR, Ma JH, Li H, Zhang J, Huang SZ, Yao XH,#, Zhou YW#, Wang CF#, Zhang DY#, Wang GP#, Liu L#,Bian XW#. Pathological Changes in the Lungs and Lymphatic Organs of Twelve COVID-19 Autopsy Cases, National Science Review, 29 September 2020, nwaa247, https://doi.org/10.1093/nsr/nwaa247. (IF= 16.693)

11、Guo YF, Duan JJ, Wang J, Li L, Wang D, Liu XZ, Yang J, Zhang HR, Lv J, Yang YJ, Yang ZY, Cai J, Liao XM, Tang T, Huang TT, Wu F, Yang XY, Wen Q, Bian XW#, Yu SC#. Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth. Sci Transl Med. 2020 Feb 19;12(531):eaax8694. (IF 16.304)

12、Shi Y, Ping YF, Zhou W, He ZC, Chen C, Bian BS, Zhang L, Chen L, Lan X, Zhang XC, Zhou K, Liu Q, Long H, Fu TW, Zhang XN, Cao MF, Huang Z, Fang X, Wang X, Feng H, Yao XH, Yu SC, Cui YH, Zhang X, Rich JN, Bao S#, Bian XW#. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. Nat Commun, 2017 Jun 1;8:15080.. (IF 12.353)

13、Wu HB, Yang S, Weng HY, Chen Q, Zhao XL, Fu WJ, Niu Q, Ping YF, Wang JM, Zhang X, Yao XH#, Bian XW#. Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. Autophagy, 2017 Sep 2;13(9):1528-1542 (IF 11.100)

14、Yi W, Cai R, Xiang D, Wang Y, Zhang M, Ma Q, Cui Y, Bian XW#, A novel photoelectrochemical strategy based on an integrative photoactive heterojunction nanomaterial and a redox cycling amplification system for ultrasensitive determination of microRNA in cells. Biosens Bioelectron. 2019 Oct 15;143:111614. (IF 10.257)

15、Wang J, Yang ZY, Guo YF, Kuang JY, Bian XW#, Yu SC#，Targeting different domains of gap junction protein to control malignant glioma. Neuro Oncol. 2018 Jun 18;20(7):885-896. （IF 10.091）